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What is HIV?

Treating HIV

Living with HIV

Other health problems

For caregivers

For ASOs

More info

HIV medicines

Question:
What one thing makes it hardest to take your medicines?
 
I just forget to take them
I do not want anyone to see me take my medicines
The medicine makes me feel worse
I do not always refill my prescriptions on time
I have trouble paying for my medicines
Other
I do not take HIV medicines right now
   

 

HIV needs several chemicals to make copies of itself. To control the virus, HIV medicines keep these chemicals from doing their jobs. The medicines work best in teams. So everyone who takes HIV medicines should take at least 3 different medicines. This group (combination) of medicines is called highly active antiretroviral therapy or HAART.

Types of HIV medicines

Some types of HIV medicines work on chemicals that are inside CD4 cells. This is where the virus makes copies of itself. There are 4 types of these medicines:

  • Nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs)
    • NRTIs and NNRTIs slow down the chemical reverse transcriptase in 2 different ways. Without this chemical, HIV cannot make new copies of itself
  • Integrase inhibitors
    • Integrase inhibitors slow integrase, the chemical HIV needs to unlock and get into the command center of the CD4 cell. If HIV cannot get into the command center, it cannot change the cell's instructions and tell the cell to start making virus parts
  • Protease inhibitors (PIs)
    • PIs stop protease, the chemical used by HIV to assemble the new virus parts into finished copies of HIV. When protease is stopped, the virus parts are put together wrong. They are bad copies of the virus. They cannot infect healthy CD4 cells

Other kinds of HIV medicines work outside CD4 cells. These medicines are called entry inhibitors. They make it very hard for HIV to enter the cells. There are 2 kinds of entry inhibitors:

  • CCR5 Inhibitors
    • HIV uses a chemical called CCR5 to know (recognize) which cells are CD4 cells. CCR5 inhibitors stop HIV from using this chemical to find CD4 cells. If HIV cannot find CD4 cells, then HIV cannot get inside them to make copies of itself
  • Fusion Inhibitors (FIs)
    • FIs physically block HIV from getting inside CD4 cells. If HIV cannot get inside, it cannot make copies of itself

HIV medicines do not cure HIV. They allow people to live longer and healthier lives. But the medicines do not get rid of the virus. Even when you are on treatment, you can still pass HIV to others. Be smart, stay safe.

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